منابع مشابه
Fluorine in medicine
Fluoride has long been known to influence the activity of various enzymes in vitro. Latterly it has been demonstrated that many effects primarily attributed to fluoride are caused by a synergistic action of fluoride plus aluminum. Fluorinated chemicals are of growing importance, with applications in medicine. Fluorine substitution has profound effects on the properties of organic compounds. The...
متن کاملFluorine.
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متن کاملFluorine in medicinal chemistry.
Fluorinated compounds are synthesized in pharmaceutical research on a routine basis and many marketed compounds contain fluorine. The present review summarizes some of the most frequently employed strategies for using fluorine substituents in medicinal chemistry. Quite often, fluorine is introduced to improve the metabolic stability by blocking metabolically labile sites. However, fluorine can ...
متن کاملFluorine in Chinese Coals
Three hundred and five coal samples were taken from the main coal mines of twenty-six provinces, autonomous regions, and municipalities of China. The method of pyrohydrolysis was applied to measure the fluorine content in the samples, which exhibit logarithmic normal frequency distributions. The range of fluorine content in dry coal varies from 25 to 1230 mg/ kg with a geometric mean of 136 mg/...
متن کاملFluorine in medicinal chemistry.
Since its first use in the steroid field in the late 1950s, the use of fluorine in medicinal chemistry has become commonplace, with the small electronegative fluorine atom being a key part of the medicinal chemist's repertoire of substitutions used to modulate all aspects of molecular properties including potency, physical chemistry and pharmacokinetics. This review will highlight the special n...
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ژورنال
عنوان ژورنال: Journal of Applied Biomedicine
سال: 2004
ISSN: 1214-021X,1214-0287
DOI: 10.32725/jab.2004.017